Longitudinal studies can vary in important ways, such as their scientific focus, their sample, and the time periods they cover.
For example, the MRC National Survey of Health and Development started collecting data from their cohort members in the 1940s, while the Millennium Cohort Study started their data collection almost 60 years later. Important changes can occur over such time intervals.
Measurement practices can be revised and modified. New technologies can also emerge. Sometimes the changes occur in how the measurements are undertaken, e.g. a shift from pen and paper to computer-based questionnaires. Additionally, the way the data are recorded or stored might change due to new developments in data management software or changes to administrative processes.
Scientific understanding can also change and develop, meaning that studies might change over time in what characteristics of their participants they measure (e.g. new questions might be added to reflect changing lifestyles or household structures). These can all impact upon the ease with which we can bring together and compare data from different studies or time periods.
One approach to addressing and overcoming these challenges is through data harmonisation.
Retrospective harmonisation involves a process of:
Documentation underpins all of this, from accessing sufficient detail about how the variables were defined and collected originally by studies, to capturing the decisions made subsequently during the harmonisation process itself (e.g. how the data were processed and changed).
Sometimes we find that there are insufficient data available to undertake harmonisation that is both valid and worthwhile. For example, too few studies might have assessed the characteristics in which we are interested, or they might have assessed those characteristics in ways that lack any compatibility.
Even where retrospective harmonisation seems possible, we may end up having to modify the data so much to derive the harmonised variable that we lose important detail and precision and the variable may no longer be informative. That is why prospective harmonisation can offer some advantages, as explained in the next section.
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